In evidence-based medicine, there is no evidence of the negative effect of Lyrica on the liver. The fact is that pregabalin is not processed in the liver, therefore its toxic effect on this organ is minimal. Regarding the influence of Lyrica on sexual function - there is no reliable information about the irreversible damage to the testicles and impotence caused by Lyrica. But the negative impact of Lyrica on the kidneys does not cause any doubt. Many patients complain of swollen limbs and pain in the lumbar region during treatment with pregabalin.